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Comparing Prodiamine, Simazine, Indaziflam, and Dithiopyr: Which Spring Pre-Emergent is Right for Your Lawn?

Seth Newell

As spring awakens, so do the weeds. Getting ahead of them with the right pre-emergent herbicide is key to a lush, healthy lawn. We'll delve into the specifics of the top four most popular pre-emergent herbicides, prodiamine, simazine, indaziflam, and dithiopyr, giving you the information needed for informed decisions.


How Pre-Emergents Work: The Foundation

Pre-emergent herbicides are a class of herbicides that function by creating a chemical barrier in the soil that inhibits germinating weed seeds. It's crucial to understand that, with few exceptions, pre-emergent herbicides target weeds before they emerge, and do not eliminate weeds that have already germinated. Optimal timing, based on soil temperature, is paramount for effectiveness.


Suburban neighborhood with two brick houses, green and brown lawns, chalk writing on sidewalk, and a red fire hydrant. Sunny day.
Left: Split Spring pre-emergent applications hold the line against untreated lawns

The Chemical Breakdown: A Closer Look

Prodiamine (brand name - Barricade):
  • Mechanism: Prodiamine inhibits cell division in susceptible weeds, preventing root development. It's particularly effective against annual grasses like crabgrass and goosegrass, as well as certain broadleaf weeds.

  • Application Details: Apply when soil temperatures consistently reach around 55°F. Granular applications should be watered in to activate the herbicide, creating a uniform barrier.

  • Longevity and Considerations: Prodiamine offers extended control, often lasting several months. However, it's less effective against established perennial weeds. Avoid application in areas where future seeding is planned, as it can inhibit desirable seed germination.

  • Pro's Note: Prodiamine is not labeled for dandelion and will not stop dandelion germination.


Simazine (brand name - Princep):
  • Mechanism: Simazine interferes with photosynthesis in susceptible weeds, disrupting their ability to produce energy. It's effective against a range of broadleaf weeds and some annual grasses.

  • Application Details: Apply when soil temperatures are between 50°F and 60°F. Rainfall or irrigation after application helps move the herbicide into the soil.

  • Longevity and Considerations: Simazine's versatility makes it suitable for lawns and ornamental landscapes. However, it can persist in the soil, potentially affecting the growth of sensitive plants. Always check label restrictions and avoid use near desirable plants susceptible to Simazine damage.

  • Pro's Note: Simazine is very effective against poa annua germination when properly timed. Consider pairing this with a more broad spectrum pre-emergent application in the fall for maximum effect.


Indaziflam (brand name - Specticle):
  • Mechanism: Indaziflam inhibits cellulose biosynthesis, disrupting cell wall formation in susceptible weeds. This provides broad-spectrum control of both annual and perennial weeds.

  • Application Details: Apply when soil temperatures reach approximately 55°F. Indaziflam's high potency requires precise application to avoid non-target plant damage.

  • Longevity and Considerations: Indaziflam offers exceptional residual control, often lasting for several months. However, its potency necessitates careful application, particularly near sensitive plants.

  • Pro's Note: Extremely expensive but highly effective, this product should not be used more than 2 consecutive years in any instance before being rotated out of use for 1 year.


Dithiopyr (brand name - Dimension):
  • Mechanism: Dithiopyr inhibits cell division in germinating weeds and also provides post-emergent control of young, susceptible weeds. This dual-action capability makes it a versatile option.

  • Application Details: Apply in early spring, as temperatures approach 55°F. Granular or spray applications are effective.

  • Longevity and Considerations: Dithiopyr's dual action is a significant advantage, but repeated use can lead to reduced effectiveness. Avoid over-application to prevent potential damage to desirable plants.

  • Pro's Note: Are you late in making your application? This is your best choice due to its limited post-emergent action not featured in the other chemicals covered here.

Practical Application and Best Practices

  • Soil Temperature Monitoring: Utilize resources like Mesonet Oklahoma’s soil temperature charts to determine optimal application timing.

  • Product Selection: Consider the specific weed species present in your lawn. A combination of pre-emergents may be necessary for comprehensive control.

  • Label Adherence: Always follow the manufacturer’s label for application rates, methods, and safety precautions.

  • Post-Application Irrigation: Lightly water the lawn after granular applications to activate the herbicide and ensure proper soil penetration.

  • Lawn and Environmental Considerations: Be mindful of your lawn type, surrounding vegetation, and potential environmental impacts. Responsible application practices are crucial.


Informed Lawn Care: Conclusions on Spring Lawn Pre-emergent Selection

Selecting the right pre-emergent herbicide is a critical step in maintaining a healthy, weed-free lawn. As you have likely surmised, there is no silver bullet when it comes to lawn care and more specifically Spring pre-emergent for your lawn. By understanding the chemical properties and application guidelines of prodiamine, simazine, indaziflam, and dithiopyr, you can make informed decisions that promote a thriving lawn throughout the spring season.


It's important to note that professional lawn care providers often utilize a diverse approach, strategically rotating these pre-emergents throughout the year. Even going so far as to rotate seasonal applications such as Spring or fall pre-emergent application active ingredients. This cyclical application method minimizes the potential for weed resistance, ensuring long-term effectiveness and optimal lawn health. By leveraging the strengths of each herbicide and varying their use, professionals can create lasting, positive change in a client's lawn.

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